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First baby born after deceased womb transplant | First baby born after deceased womb transplant |
(about 11 hours later) | |
A healthy baby girl has been born using a womb transplanted from a dead body. | A healthy baby girl has been born using a womb transplanted from a dead body. |
The 10-hour transplant operation - and later fertility treatment - took place in São Paulo, Brazil, in 2016. The mother, 32, was born without a womb. | |
There have been 39 womb transplants using a live donor, including mothers donating their womb to their daughter, resulting in 11 babies. | There have been 39 womb transplants using a live donor, including mothers donating their womb to their daughter, resulting in 11 babies. |
But the 10 previous transplants from a dead donor have failed or resulted in miscarriage. | But the 10 previous transplants from a dead donor have failed or resulted in miscarriage. |
Given drugs | Given drugs |
In this case, the womb donor was a mother of three in her mid-40s who died from bleeding on the brain. | In this case, the womb donor was a mother of three in her mid-40s who died from bleeding on the brain. |
The recipient had Mayer-Rokitansky-Küster-Hauser syndrome, which affects about one in every 4,500 women and results in the vagina and uterus (womb) failing to form properly. | The recipient had Mayer-Rokitansky-Küster-Hauser syndrome, which affects about one in every 4,500 women and results in the vagina and uterus (womb) failing to form properly. |
However, her ovaries were fine. And doctors were able to remove eggs, fertilise them with the father-to-be's sperm and freeze them. | However, her ovaries were fine. And doctors were able to remove eggs, fertilise them with the father-to-be's sperm and freeze them. |
The woman was given drugs that weakened her immune system to prevent her body attacking and rejecting the transplant. | The woman was given drugs that weakened her immune system to prevent her body attacking and rejecting the transplant. |
'Medical milestone' | 'Medical milestone' |
And about six weeks later, she started having periods. | And about six weeks later, she started having periods. |
After seven months, the fertilised eggs were implanted. | After seven months, the fertilised eggs were implanted. |
And, after a normal pregnancy, a 6lb (2.5kg) baby was delivered by Caesarean section on 15 December 2017. | And, after a normal pregnancy, a 6lb (2.5kg) baby was delivered by Caesarean section on 15 December 2017. |
Dr Dani Ejzenberg, from Hospital das Clínicas in São Paulo, said: "The first uterus transplants from live donors were a medical milestone, creating the possibility of childbirth for many infertile women with access to suitable donors and the needed medical facilities. | |
'Extremely exciting' | 'Extremely exciting' |
"However, the need for a live donor is a major limitation as donors are rare, typically being willing and eligible family members or close friends." | "However, the need for a live donor is a major limitation as donors are rare, typically being willing and eligible family members or close friends." |
Dr Srdjan Saso, from Imperial College London, said the results were "extremely exciting". | Dr Srdjan Saso, from Imperial College London, said the results were "extremely exciting". |
"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks." | "It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks." |