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| Cardiff hospital trials cooling patients after cardiac arrest | Cardiff hospital trials cooling patients after cardiac arrest |
| (about 3 hours later) | |
| A year ago, Andrew Barnett collapsed and his heart stopped beating, as he played football with his young son. | A year ago, Andrew Barnett collapsed and his heart stopped beating, as he played football with his young son. |
| Luckily, it was at on a pitch at a Cardiff leisure centre - which had a defibrillator - and the manager knew CPR techniques. | Luckily, it was at on a pitch at a Cardiff leisure centre - which had a defibrillator - and the manager knew CPR techniques. |
| Andrew, 46, was revived and became part of a hospital trial to see if cooling the body in intensive care helps recovery. | Andrew, 46, was revived and became part of a hospital trial to see if cooling the body in intensive care helps recovery. |
| The event was a complete blank but he realises how close to death he came. | The event was a complete blank but he realises how close to death he came. |
| The cooling trial, involving nine UK hospitals, is being led by researchers at the University Hospital of Wales, Cardiff. | |
| Altogether, 1,900 patients worldwide are part of the trial, called TTM2. | Altogether, 1,900 patients worldwide are part of the trial, called TTM2. |
| Half of patients were cooled down, often with pads and cold water, to bring them down to a temperature of 33C - our normal body temperature is 37.5C. They're kept like that for 24 hours, as well as getting all the usual life-saving treatment. | Half of patients were cooled down, often with pads and cold water, to bring them down to a temperature of 33C - our normal body temperature is 37.5C. They're kept like that for 24 hours, as well as getting all the usual life-saving treatment. |
| The other half are kept at normal temperature - but not allowed to get hot either - so the results can eventually be compared. | The other half are kept at normal temperature - but not allowed to get hot either - so the results can eventually be compared. |
| Dr Matt Morgan, intensive care consultant and researcher, is one of those leading the trial. | Dr Matt Morgan, intensive care consultant and researcher, is one of those leading the trial. |
| "It is looking at the importance of protecting the brain after someone suffers a cardiac arrest - and there have been theories since the 1960s of cooling the body to help protect the brain," said Dr Morgan. | "It is looking at the importance of protecting the brain after someone suffers a cardiac arrest - and there have been theories since the 1960s of cooling the body to help protect the brain," said Dr Morgan. |
| "It's been used quite extensively in intensive care worldwide but what we really don't know is if that's truly beneficial." | "It's been used quite extensively in intensive care worldwide but what we really don't know is if that's truly beneficial." |
| 'I couldn't believe it' | 'I couldn't believe it' |
| It was a during a "fathers and sons" football match the week before Christmas, with his seven-year-old son Seb, that Andrew collapsed. | It was a during a "fathers and sons" football match the week before Christmas, with his seven-year-old son Seb, that Andrew collapsed. |
| He led an active lifestyle and works for a sportswear company but did not know that he had a blocked artery. | He led an active lifestyle and works for a sportswear company but did not know that he had a blocked artery. |
| "It was a usual day," he recalled, ahead of the game on Astroturf at Eastern Leisure Centre in Llanrumney. | "It was a usual day," he recalled, ahead of the game on Astroturf at Eastern Leisure Centre in Llanrumney. |
| "I'd worked from home and been for a swim at lunchtime and brought my son up for the game in the evening. I have very little recollection, only what I've been told by the people who were there. | "I'd worked from home and been for a swim at lunchtime and brought my son up for the game in the evening. I have very little recollection, only what I've been told by the people who were there. |
| "I don't remember the game at all or falling over. They grouped around me to see what was wrong but I was completely out so they knew it was something serious." | "I don't remember the game at all or falling over. They grouped around me to see what was wrong but I was completely out so they knew it was something serious." |
| Ben Clarke, leisure centre duty manager, was in the office when he was told about Andrew's collapse. | Ben Clarke, leisure centre duty manager, was in the office when he was told about Andrew's collapse. |
| "I grabbed the defibrillator from reception and ran out - as soon as I got there I could see he was not in a good way, he was unconscious," he said. | "I grabbed the defibrillator from reception and ran out - as soon as I got there I could see he was not in a good way, he was unconscious," he said. |
| "I knew he'd gone - his heart had stopped. I started CPR - a colleague started unpacking the defib. I did four or five cycles of CPR and the machine showed he needed a shock. He was a grey-blue colour and it was clear he was 'dead'". | "I knew he'd gone - his heart had stopped. I started CPR - a colleague started unpacking the defib. I did four or five cycles of CPR and the machine showed he needed a shock. He was a grey-blue colour and it was clear he was 'dead'". |
| The defibrillator also indicated he needed two more cycles of CPR - and Ben did this until Andrew started to show signs of life and the ambulance arrived. | The defibrillator also indicated he needed two more cycles of CPR - and Ben did this until Andrew started to show signs of life and the ambulance arrived. |
| When Andrew was admitted to the University Hospital of Wales, he was sedated and included in the trial - until he was taken off both the following day. | When Andrew was admitted to the University Hospital of Wales, he was sedated and included in the trial - until he was taken off both the following day. |
| He cannot remember anything that happened the previous week - only waking up in the critical care unit the following morning. | He cannot remember anything that happened the previous week - only waking up in the critical care unit the following morning. |
| "The first recollection I had was when they told me I'd had a cardiac arrest - I looked at the wall and I couldn't believe it, it was the sort of thing that happened to someone else." | "The first recollection I had was when they told me I'd had a cardiac arrest - I looked at the wall and I couldn't believe it, it was the sort of thing that happened to someone else." |
| About 6,000 people in Wales need resuscitating outside hospitals every year but only about 10% of these patients ever recover and leave hospital. Andrew is one of the lucky ones. | About 6,000 people in Wales need resuscitating outside hospitals every year but only about 10% of these patients ever recover and leave hospital. Andrew is one of the lucky ones. |
| For Ben, it emphasised the importance of defibrillators being available in public places. | For Ben, it emphasised the importance of defibrillators being available in public places. |
| "It was good to know you'd helped save someone," he said. "Me and Andrew have met up a couple of times for a drink - we've formed a friendship out of something which was negative." | "It was good to know you'd helped save someone," he said. "Me and Andrew have met up a couple of times for a drink - we've formed a friendship out of something which was negative." |
| How is the UK involved? | How is the UK involved? |
| The UK has contributed 392 of the 1,900 patients in the trial, which started in Sweden. | The UK has contributed 392 of the 1,900 patients in the trial, which started in Sweden. |
| Hospitals taking part are: | Hospitals taking part are: |
| How will patients find out if they are part of the trial? | How will patients find out if they are part of the trial? |
| The trial presents challenges over consent because, in intensive care, people are often unconscious and their family traumatised. | The trial presents challenges over consent because, in intensive care, people are often unconscious and their family traumatised. |
| Staff will approach patients or families about the trial later, after the critical phase has passed. | Staff will approach patients or families about the trial later, after the critical phase has passed. |
| But Dr Morgan is hoping they will understand the need to find out if the approach really is beneficial. | But Dr Morgan is hoping they will understand the need to find out if the approach really is beneficial. |
| "We really, genuinely don't know what's best - that's why this trial is being done at all. If we did know best, there wouldn't be a trial." | "We really, genuinely don't know what's best - that's why this trial is being done at all. If we did know best, there wouldn't be a trial." |
| Jade Cole, lead critical research nurse, said they looked at a range of criteria but patients needed to be have been revived for at least 20 minutes before they are appropriate for the trial. Patient safety and family wishes were a priority, she said. | Jade Cole, lead critical research nurse, said they looked at a range of criteria but patients needed to be have been revived for at least 20 minutes before they are appropriate for the trial. Patient safety and family wishes were a priority, she said. |
| "The family can veto what the patient would want because we don't want to upset a family in a very stressful situation," she said. | "The family can veto what the patient would want because we don't want to upset a family in a very stressful situation," she said. |
| "I've done it hundreds of times but I've never had a patient unhappy about being involved in a research study - they have always been positive. They can be a bit shocked that you need to do research in intensive care." | "I've done it hundreds of times but I've never had a patient unhappy about being involved in a research study - they have always been positive. They can be a bit shocked that you need to do research in intensive care." |
| Wales has contributed 54 patients to the trial, more than Germany or Italy. They're expecting the first results later this year. | Wales has contributed 54 patients to the trial, more than Germany or Italy. They're expecting the first results later this year. |
| 'I had a cardiac arrest and a vet saved my life' | 'I had a cardiac arrest and a vet saved my life' |
| Pop star tells pupils how CPR saved him | Pop star tells pupils how CPR saved him |
| Dr Matt Wise, lead UK investigator in the study and critical care consultant at UHW, added: "The risk of not conducting studies like this is that we'll carry on in many patients giving suboptimal or incorrect therapy. | Dr Matt Wise, lead UK investigator in the study and critical care consultant at UHW, added: "The risk of not conducting studies like this is that we'll carry on in many patients giving suboptimal or incorrect therapy. |
| "I remember talking at a conference in Brussels... and someone at the end asked me: If you have a cardiac arrest what temperature would you want to be? And I said - I'd want to be in the trial." | "I remember talking at a conference in Brussels... and someone at the end asked me: If you have a cardiac arrest what temperature would you want to be? And I said - I'd want to be in the trial." |
| As for being part of the cooling trial, Andrew said he was "absolutely fine for that to happen". | As for being part of the cooling trial, Andrew said he was "absolutely fine for that to happen". |
| "I went into casualty unconscious," he said. "It's key that patients going in become part of the process and non-consent because we all benefit from the medicine and the research that they're doing. It's also about how well you survive, so that's key as well." | "I went into casualty unconscious," he said. "It's key that patients going in become part of the process and non-consent because we all benefit from the medicine and the research that they're doing. It's also about how well you survive, so that's key as well." |
| He spent two weeks in hospital and had a further four months off work. | He spent two weeks in hospital and had a further four months off work. |
| "I'm fine now - back to my normal work and day life. I'm back playing football with my son - training every Monday. You realise it can be taken away in an instance." | "I'm fine now - back to my normal work and day life. I'm back playing football with my son - training every Monday. You realise it can be taken away in an instance." |