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Hopes dashed as coronavirus drug remdesivir fails first trial Hopes dashed as coronavirus drug remdesivir 'fails first trial'
(about 11 hours later)
A potential antiviral drug for the coronavirus has reportedly failed in its first randomised clinical trial.A potential antiviral drug for the coronavirus has reportedly failed in its first randomised clinical trial.
There had been widespread hope that remdesivir could treat Covid-19.There had been widespread hope that remdesivir could treat Covid-19.
But a Chinese trial showed that the drug had not been successful, according to draft documents accidentally published by the World Health Organization.But a Chinese trial showed that the drug had not been successful, according to draft documents accidentally published by the World Health Organization.
The drug did not improve patients' condition or reduce the pathogen's presence in the bloodstream, it said.The drug did not improve patients' condition or reduce the pathogen's presence in the bloodstream, it said.
The US firm behind the drug, Gilead Sciences, said the document had mischaracterised the study.The US firm behind the drug, Gilead Sciences, said the document had mischaracterised the study.
What do we know about the study?What do we know about the study?
News of the failed trial spread after the WHO posted details on its clinical trials database, before it was removed. The WHO has since confirmed the draft report was mistakenly uploaded.News of the failed trial spread after the WHO posted details on its clinical trials database, before it was removed. The WHO has since confirmed the draft report was mistakenly uploaded.
It showed that researchers studied 237 patients, administering the drug to 158 and comparing their progress with the remaining 79, who received a placebo.It showed that researchers studied 237 patients, administering the drug to 158 and comparing their progress with the remaining 79, who received a placebo.
After a month, 13.9% of the patients taking the drug had died compared to 12.8% of those receiving the placebo. The trial was stopped early because of side-effects.After a month, 13.9% of the patients taking the drug had died compared to 12.8% of those receiving the placebo. The trial was stopped early because of side-effects.
"Remdesivir was not associated with clinical or virological benefits," the summary states."Remdesivir was not associated with clinical or virological benefits," the summary states.
All three main US stock indexes fell back from gains of over 1% after the news broke over the trial.All three main US stock indexes fell back from gains of over 1% after the news broke over the trial.
What do I need to know about the coronavirus?What do I need to know about the coronavirus?
What has the company said?What has the company said?
Gilead has disputed the WHO post.Gilead has disputed the WHO post.
"We believe the post included inappropriate characterisations of the study," a spokesman for Gilead said, adding that it was terminated early due to low enrolment and was therefore not statistically meaningful."We believe the post included inappropriate characterisations of the study," a spokesman for Gilead said, adding that it was terminated early due to low enrolment and was therefore not statistically meaningful.
"As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease," he said."As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease," he said.
This does not spell the end of the road for the drug, however, and several continuing trials will soon provide a clearer picture on the drug's use.This does not spell the end of the road for the drug, however, and several continuing trials will soon provide a clearer picture on the drug's use.