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What is known about new Covid variant XBB.1.5? What is known about new Covid variant XBB.1.5?
(32 minutes later)
A new Covid sub-variant is causing some concern in the US, where it is spreading rapidly.A new Covid sub-variant is causing some concern in the US, where it is spreading rapidly.
Some cases have been recorded in the UK, so what do you need to know about XBB.1.5? Some cases have also been recorded in the UK, so what do you need to know about XBB.1.5?
What is XBB.1.5?What is XBB.1.5?
It is yet another offshoot of the globally dominant Omicron Covid variant, which itself followed the earlier Alpha, Beta, Gamma and Delta variants. It is yet another offshoot of the globally-dominant Omicron Covid variant. Omicron has outperformed the earlier Alpha, Beta, Gamma and Delta coronavirus variants since emerging in late 2021.
Omicron has outperformed all previous versions of coronavirus since it emerged in late 2021, and has given rise to many sub-variants which are even more contagious than the original. Omicron has also given rise to many more contagious sub-variants.
Symptoms of XBB.1.5 are thought to be similar to those of previous Omicron strains, but it's still too early to confirm this. Most people experience cold-like symptoms. Symptoms of XBB.1.5 are thought to be similar to those of previous Omicron strains. Most people experience cold-like symptoms.
Is XBB.1.5 more infectious or dangerous than earlier variants? Is XBB.1.5 more infectious or dangerous?
XBB.1.5 itself evolved from XBB, which began circulating in the UK in September 2022, but which has not been classified as a so-called "variant of concern" by health authorities. XBB.1.5 evolved from XBB, which began circulating in the UK in September 2022.
XBB had a mutation that helped it beat the body's immune defences, but this same quality also reduced its ability to infect human cells.XBB had a mutation that helped it beat the body's immune defences, but this same quality also reduced its ability to infect human cells.
Prof Wendy Barclay from Imperial College London said XBB.1.5 had a mutation known as F486P, which restores this ability to bind to cells while continuing to evade immunity. That makes it spread more easily. Prof Wendy Barclay from Imperial College London said XBB.1.5 has a mutation known as F486P, which restores this ability to bind to cells while continuing to evade immunity. That makes it spread more easily.
She said these evolutionary changes were like "stepping stones", as the virus evolves to find new ways of bypassing the body's self-defence mechanisms. She said these evolutionary changes were like "stepping stones", as the virus evolves to find new ways of bypassing the body's defence mechanisms.
Scientists from the World Health Organization (WHO) confirmed on Wednesday that XBB.1.5 has a "growth advantage" above all other sub-variants seen so far. The Wellcome Sanger Institute in Cambridge is sequencing at least 5,000 Covid samples a week, as part of continuing efforts to track variants.
But they said there was no indication it was more serious or harmful than previous Omicron variants. The institute's Dr Ewan Harrison thinks XBB.1.5 probably emerged when someone got infected with two different Omicron types:
The WHO said it would keep a close watch on lab studies, hospital data and infection rates to find out more about its impact on patients. "A bit of the genome from one virus gets joined up with another bit from a second virus, and they merge, and that goes on to transmit."
Who can get a Covid booster this winter? The World Health Organization (WHO) confirmed that XBB.1.5 has a "growth advantage" over other sub-variants seen so far.
But the WHO said there was no indication so far that it was more serious or harmful than previous Omicron variants.
Where is XBB.1.5 spreading?Where is XBB.1.5 spreading?
Over 40% of Covid cases in the United States are estimated to be caused by XBB.1.5, making it the dominant strain in the country. Over 40% of Covid cases in the United States are thought to be caused by XBB.1.5, making it the dominant strain.
At the beginning of December, it accounted for only 4% of cases so it has quickly overtaken other versions of Omicron. At the beginning of December, it accounted for only 4% of cases, so it has quickly overtaken other versions of Omicron.
Covid hospital admissions have been rising in recent weeks across the US. Covid hospital admissions have been rising in recent weeks across the US, and the government has restarted its free testing programme.
US brings back free at-home Covid testsUS brings back free at-home Covid tests
Could the XBB.1.5 variant take off in the UK?Could the XBB.1.5 variant take off in the UK?
Nothing is certain, but it does look likely. It looks likely. The UK had five Omicron waves in 2022, and further spikes in cases seem inevitable.
The UK had five Omicron waves in 2022, and further spikes in cases are inevitable. Figures for the week to Saturday 17 December from Wellcome Sanger suggested that one in 25 Covid cases in the UK were XBB.1.5.
Figures for the week to Saturday 17 December from the Sanger Institute in Cambridge suggested that one in 25 Covid cases in the UK were XBB.1.5. But that was based on just nine samples, so we need to wait to get a better picture.
But that was based on just nine samples, so we'll need to wait to get a better picture.
The UK Health Security Agency is due to release a report on variants spreading in the UK next week.The UK Health Security Agency is due to release a report on variants spreading in the UK next week.
Prof Barclay said she expected more hospitalisations in the UK if the variant takes off here, "as we expect it to do".Prof Barclay said she expected more hospitalisations in the UK if the variant takes off here, "as we expect it to do".
Prof Paul Hunter from the University of East Anglia, said: "The balance of probabilities is that XBB.1.5 will trigger a wave here later this month, but we can't be sure."
NHS England has said the fears of a "twindemic" of Covid and flu have already been realised, with both viruses putting strain on an already stretched NHS.NHS England has said the fears of a "twindemic" of Covid and flu have already been realised, with both viruses putting strain on an already stretched NHS.
Covid putting massive pressure on NHS - Barclay Who can get a Covid booster this winter?
How to look after yourself if you get Covid
Covid vaccines provide most people with good protection against serious illnessCovid vaccines provide most people with good protection against serious illness
Are scientists worried about XBB.1.5?Are scientists worried about XBB.1.5?
Prof Barclay said she was not especially concerned about the general UK population because there was "no indication" that XBB.1.5 would "break 800through" the protection against severe illness provided by vaccines. Prof Barclay said she was not especially concerned about the general UK population because there was "no indication" that XBB.1.5 would "break through" the protection against severe illness provided by vaccines.
But she is worried about its effect on the vulnerable, including the immunocompromised, who get less benefit from Covid jabs. But she is worried about the potential effect on the vulnerable, including the immunocompromised, who get less benefit from Covid jabs.
Prof Hunter said he'd seen no evidence that XBB.1.5 was more virulent, meaning it was no more likely to "put you in hospital or kill you" than existing Omicron variants.
He added: "It's ironic that everyone is focussing on possible variants emerging from China, but XBB.1.5 came out of the US."
Prof David Heymann from the London School of Hygiene and Tropical Medicine acknowledged that there was still a fair amount to learn about this latest variant.Prof David Heymann from the London School of Hygiene and Tropical Medicine acknowledged that there was still a fair amount to learn about this latest variant.
But he said it was unlikely to cause major problems in countries like the UK which have high levels of vaccination and previous infections.But he said it was unlikely to cause major problems in countries like the UK which have high levels of vaccination and previous infections.
His concern was for countries like China, where there was both low take-up of vaccines and little natural immunity because of prolonged lockdowns.His concern was for countries like China, where there was both low take-up of vaccines and little natural immunity because of prolonged lockdowns.
"China needs to share clinical information on people infected in order to see how the variant behaves in a non-immune population," Prof Heymann said."China needs to share clinical information on people infected in order to see how the variant behaves in a non-immune population," Prof Heymann said.
How is China trying to beat its latest Covid surge?How is China trying to beat its latest Covid surge?