Heavy snow in the Borders has led police to warn people not to travel unless it is "absolutely necessary".
At least 250 schools will be shut across Scotland on Thursday as freezing conditions continue to cause disruption.
Between 15cm and 20cm of snow left many roads closed or impassable, with many motorists becoming stuck.
Snow and ice are still affecting travel around the country and 700 homes in Kelso, Duns and Coldstream were without electricity after heavy snow.
Snow and ice has also disrupted travel in the Highlands and Islands. A woman died and two other people were hurt in a car crash in Shetland.
Earlier on Wednesday a woman died and two people were injured in Shetland after a car crashed.
All schools in the Borders are closed, as are those in East Lothian, Midlothian, Aberdeenshire and Shetland.
Forecasters warned temperatures could fall as low as -20C at the weekend.
All 45 nursery, primary and high schools in East Lothian will be closed on Thursday.
Hundreds of schools were closed on Wednesday and trains between Edinburgh and Glasgow were suspended for a period in the evening due to frozen points.
Salt supplies
More snow has been predicted with a warning that it will be heavy overnight in the Scottish Borders, where the local council is urging people to stay at home.
Borders Council said its schools would remain closed until Monday.
Businesses leaders said that the bad weather was costing Scotland's economy up to £60m a day.
Dumfries and Galloway is the latest council to warn that it is running short of salt for the roads.
It said it was down to "barely one day's supply" - with the severe weather predicted to last well into next week and perhaps for as long as a fortnight.
The Scottish government said it was trying to ensure that councils get the salt supplies they need.
But Finance Secretary John Swinney said the spread of the snowy conditions elsewhere in the UK had put further pressure on reserves of grit for Scotland's roads.
Speaking on BBC Radio Scotland's Good Morning Scotland, Mr Swinney said: "Quite clearly the stocks are being diminished very quickly.
"We are working very hard in collaboration with local authorities across Scotland to make sure that we manage these salt supplies, and make sure we support any local authority that finds itself in difficulty, and we will give every effort we can to do that."
Mr Swinney added the government wanted to avoid the shortages getting worse.
Heavy snow in the Borders has led police to warn people not to travel
Police in the Borders urged people not to travel and all Borders First Bus services were cancelled.
The council said trips should only be made if it was a "matter of life and death".
Many roads were closed including the A7 in various places, the A703 northbound towards Edinburgh, and the A697, where two cars became stuck.
The snow ploughs sent to help them also became stranded.
In Shetland, a woman died and two other people were airlifted to hospital after their car crashed into a burn two miles from Sand at about 2040 GMT.
There were also problems on routes to the south of Edinburgh.
The A702 is closed at Hillend and conditions are difficult in Biggar.
The A1 is badly affected between Edinburgh and Dunbar.
There are also problems on the A68 at Soutra in Midlothian where drivers have been stuck.
The A701 Dumfries to Edinburgh road is closed at Moffat and there is heavy snow on the M74 around junction 13 Abington in South Lanarkshire.
Routes closed
In the north and north-east the usual higher level routes are closed.
The A9 has been mostly cleared of snow and is now passable with care.
Northern Constabulary said that sections of 12 other roads were closed because of snow. They include A939 Grantown on Spey to Forres and B885 Struan to Portree in Skye.
On the trains, there are problems between Inverness and Aberdeen and Inverness and Perth.
Inverness, Glasgow an Edinburgh airports are open, but Aberdeen is closed.
The bad weather is also affecting NHS services in the Borders.
All routine and outpatient appointments have been cancelled at Borders General Hospital, health centres and community hospitals.
The Met Office said the freezing conditions could affect Scotland for another fortnight.
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