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| Why are we still using electroconvulsive therapy? | Why are we still using electroconvulsive therapy? |
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| The idea of treating a psychiatric illness by passing a jolt of electricity through the brain was one of the most controversial in 20th Century medicine. So why are we still using a procedure described by its critics as barbaric and ineffective? | The idea of treating a psychiatric illness by passing a jolt of electricity through the brain was one of the most controversial in 20th Century medicine. So why are we still using a procedure described by its critics as barbaric and ineffective? |
| Sixty-four-year-old John Wattie says his breakdown in the late 1990s was triggered by the collapse of his marriage and stress at work. | Sixty-four-year-old John Wattie says his breakdown in the late 1990s was triggered by the collapse of his marriage and stress at work. |
| "We had a nice house and a nice lifestyle, but it was all just crumbling away. My depression was starting to overwhelm me. I lost control, I became violent," he explains. | "We had a nice house and a nice lifestyle, but it was all just crumbling away. My depression was starting to overwhelm me. I lost control, I became violent," he explains. |
| John likens the feeling to being in a hole, a hole he could not get out of despite courses of pills and talking therapies. | John likens the feeling to being in a hole, a hole he could not get out of despite courses of pills and talking therapies. |
| But now, he says, all of that has changed thanks to what is one of the least understood treatments in psychiatry - electroconvulsive therapy (ECT). | But now, he says, all of that has changed thanks to what is one of the least understood treatments in psychiatry - electroconvulsive therapy (ECT). |
| "Before ECT I was the walking dead. I had no interest in life, I just wanted to disappear. After ECT I felt like there was a way out of it. I felt dramatically better." | "Before ECT I was the walking dead. I had no interest in life, I just wanted to disappear. After ECT I felt like there was a way out of it. I felt dramatically better." |
| The use of electricity to treat mental illness started out as an experiment. In the 1930s psychiatrists noticed some heavily distressed patients would suddenly improve after an epileptic fit. | The use of electricity to treat mental illness started out as an experiment. In the 1930s psychiatrists noticed some heavily distressed patients would suddenly improve after an epileptic fit. |
| Passing a strong electric current through the brain could trigger a similar seizure and - they hoped - a similar response. | Passing a strong electric current through the brain could trigger a similar seizure and - they hoped - a similar response. |
| By the 1960s it was being widely used to treat a variety of conditions, notably severe depression. | By the 1960s it was being widely used to treat a variety of conditions, notably severe depression. |
| But as the old mental asylums closed down and aggressive physical interventions like lobotomies fell out of favour, so too did electroshock treatment, as ECT was previously known. | But as the old mental asylums closed down and aggressive physical interventions like lobotomies fell out of favour, so too did electroshock treatment, as ECT was previously known. |
| The infamous ECT scene in One Flew Over the Cuckoo's Nest cemented the idea in the public's mind of a brutal treatment, although by the time the film was released in 1975 it was very rarely given without a general anaesthetic. | The infamous ECT scene in One Flew Over the Cuckoo's Nest cemented the idea in the public's mind of a brutal treatment, although by the time the film was released in 1975 it was very rarely given without a general anaesthetic. |
| Perhaps more significantly, new anti-depressant drugs introduced in the 1970-80s gave doctors new ways to treat long-term mental illness. | Perhaps more significantly, new anti-depressant drugs introduced in the 1970-80s gave doctors new ways to treat long-term mental illness. |
| But for a group of the most severely depressed patients, ECT has remained one of the last options on the table when other therapies have failed. | But for a group of the most severely depressed patients, ECT has remained one of the last options on the table when other therapies have failed. |
| Annually in the UK around 4,000 patients, of which John is one, still undergo ECT. | Annually in the UK around 4,000 patients, of which John is one, still undergo ECT. |
| "It's not intuitive that causing seizures can be good for depression but it's long been determined that ECT is effective," says Professor Ian Reid at the University of Aberdeen, who heads up the team treating John. | "It's not intuitive that causing seizures can be good for depression but it's long been determined that ECT is effective," says Professor Ian Reid at the University of Aberdeen, who heads up the team treating John. |
| ECT procedure (Warning: Some may find images upsetting) | ECT procedure (Warning: Some may find images upsetting) |
| In the 75 years since ECT was first used scientists have argued about why and how it might work. | In the 75 years since ECT was first used scientists have argued about why and how it might work. |
| The latest theories build on the idea of hyperconnectivity. This new concept in psychiatry suggests parts of the brain can start to transmit signals in a dysfunctional way, overloading the system and leading to conditions from depression to autism. | The latest theories build on the idea of hyperconnectivity. This new concept in psychiatry suggests parts of the brain can start to transmit signals in a dysfunctional way, overloading the system and leading to conditions from depression to autism. |
| Prof Reid and his colleagues used MRI scanners to map the brains of nine patients before and after treatment. | Prof Reid and his colleagues used MRI scanners to map the brains of nine patients before and after treatment. |
| In an academic paper in 2012 they claimed ECT can "turn down" overactive connections as they start to build, effectively resetting the brain's wiring. | In an academic paper in 2012 they claimed ECT can "turn down" overactive connections as they start to build, effectively resetting the brain's wiring. |
| "For the first time we can point to something that ECT does in the brain that makes sense in the context of what we think is wrong in people who are depressed," Prof Reid says. "The change that we see in the brain connections after ECT reflects the change that we see in the symptom profile of patients who generally see a big improvement." | "For the first time we can point to something that ECT does in the brain that makes sense in the context of what we think is wrong in people who are depressed," Prof Reid says. "The change that we see in the brain connections after ECT reflects the change that we see in the symptom profile of patients who generally see a big improvement." |
| But passing electricity through the most complex organ in the body is not without risk. Many doctors think the side-effects of ECT can be so serious they outweigh any possible benefits. | But passing electricity through the most complex organ in the body is not without risk. Many doctors think the side-effects of ECT can be so serious they outweigh any possible benefits. |
| Helen Crane was given two rounds of ECT in the late 1990s. She now blames the second course for wiping years of her memory, from trips abroad to dramatic family events. | Helen Crane was given two rounds of ECT in the late 1990s. She now blames the second course for wiping years of her memory, from trips abroad to dramatic family events. |
| "After ECT, I had this instinct that something was wrong with my mother. I said to my husband 'What's happened to my mother?' And then he had to tell me that she'd died nearly two years earlier," she says. | "After ECT, I had this instinct that something was wrong with my mother. I said to my husband 'What's happened to my mother?' And then he had to tell me that she'd died nearly two years earlier," she says. |
| "It was devastating going through bereavement again. How on Earth could I have forgotten something so important and fundamental? Getting words wrong is frustrating, but to have lost really basic stuff in your life is awful." | "It was devastating going through bereavement again. How on Earth could I have forgotten something so important and fundamental? Getting words wrong is frustrating, but to have lost really basic stuff in your life is awful." |
| Critics of ECT claim around a third of patients will notice some sort of permanent change from memory loss to problems with speech and basic skills like addition. | Critics of ECT claim around a third of patients will notice some sort of permanent change from memory loss to problems with speech and basic skills like addition. |
| "What happens is a little like recharging a car battery," says the psychologist Dr John Read from the University of Liverpool, one of the most vocal critics of ECT. | "What happens is a little like recharging a car battery," says the psychologist Dr John Read from the University of Liverpool, one of the most vocal critics of ECT. |
| "It's not difficult to get artificial changes in the brain, you could do it with cocaine, but it doesn't last and three or four weeks later the person is either back at the same level of depression or many studies show worse levels of depression." | "It's not difficult to get artificial changes in the brain, you could do it with cocaine, but it doesn't last and three or four weeks later the person is either back at the same level of depression or many studies show worse levels of depression." |
| Opponents say that ECT patients can enter into an addictive cycle of repeated treatment and that any improvement beyond the very short term is likely to be little more than an extreme form of the placebo effect, with patients benefitting psychologically from the extra care and medical attention associated with ECT. | Opponents say that ECT patients can enter into an addictive cycle of repeated treatment and that any improvement beyond the very short term is likely to be little more than an extreme form of the placebo effect, with patients benefitting psychologically from the extra care and medical attention associated with ECT. |
| "It's not in any way addressing the cause of their depression. It's systematically and gradually wiping out their memory and cognitive function," says Dr John Read. | "It's not in any way addressing the cause of their depression. It's systematically and gradually wiping out their memory and cognitive function," says Dr John Read. |
| "I'm convinced that in 10 or 15 years we will have put ECT in same rubbish bin of historical treatments as lobotomies and surprise baths that have been discarded over time." | "I'm convinced that in 10 or 15 years we will have put ECT in same rubbish bin of historical treatments as lobotomies and surprise baths that have been discarded over time." |
| But Prof Reid says when weighing up the risks and benefits of the treatment "it is important to realise that the people who are treated with ECT are suffering from an illness that could kill them". | But Prof Reid says when weighing up the risks and benefits of the treatment "it is important to realise that the people who are treated with ECT are suffering from an illness that could kill them". |
| "Depression is associated with a measurable mortality. It can be lethal. Untreated patients can die." | "Depression is associated with a measurable mortality. It can be lethal. Untreated patients can die." |
| The team in Aberdeen now hope their research will allow drug companies to develop new treatments that mimic some of the effects of electroconvulsive therapy. | The team in Aberdeen now hope their research will allow drug companies to develop new treatments that mimic some of the effects of electroconvulsive therapy. |
| "One of the exciting things about being able to identify a change in the brain related to a psychiatric disorder is that it might make it easier to diagnose that condition over time," Prof Reid says. | "One of the exciting things about being able to identify a change in the brain related to a psychiatric disorder is that it might make it easier to diagnose that condition over time," Prof Reid says. |
| "No one would be happier than me if we could reproduce the changes that ECT has on the brain in a less invasive and safer way for patients." | "No one would be happier than me if we could reproduce the changes that ECT has on the brain in a less invasive and safer way for patients." |