Dementia progress 'achingly slow' says global envoy
Dementia is 'one of greatest enemies of humanity' - PM
(about 9 hours later)
Progress on research and treatment for dementia has been "achingly slow", an expert says ahead of a London summit.
A "big, bold global push" is needed to beat dementia, David Cameron has told a summit in London.
Dr Dennis Gillings said a pledge by G8 countries to find a cure or treatment by 2025 would be "impossible" without better incentives for investment.
He pledged to accelerate progress on dementia drugs, by increasing funding and making new drugs more accessible.
Dr Gillings, appointed world dementia envoy by UK PM David Cameron six month ago, called for faster and cheaper clinical trials for dementia drugs.
The prime minister was speaking to an audience of 300 experts who have pledged to find a cure by 2025.
Hosting the event, the PM will call for a "big, bold global push" on dementia.
He wants a team of experts to report back to him by October on how drugs companies can be encouraged to develop new dementia medicines.
He is expected to pledge a new drive by the UK to discover new drugs and treatment for the condition, and a focus on how to bring forward specific proposals on patent extensions as well as how to give patients earlier access to new drugs.
In his speech, the prime minister told experts that dementia is one of the "greatest enemies of humanity".
Mr Cameron is expected to tell the summit: "In the UK alone there are around 800,000 people living with dementia, worldwide that number is 40m - and it is set to double every 20 years.
"We are renewing our commitment to say by 2025 we want to find a cure to dementia. We should treat this as a disease rather than as some natural part of ageing," he said.
"We have to fight to cure it. I know some people will say that it's not possible, but we have seen with cancer what medicine can achieve."
He said there was a need to develop more drugs and get them to patients more quickly. For that to happen, international collaboration and more money for dementia research was needed, he said.
'Special case'
Speaking to an audience of global dementia and finance specialists, David Cameron said he would speed up progress on dementia drugs by getting experts to come up with new proposals on areas such as drug patent extensions, by October.
Six months since the UK hosted a G8 summit on the disease at which the 2025 target was set, the prime minister is speaking at a follow-up event in central London where he will commit to accelerating progress on dementia drugs.
He added: "Something like £50m a year is being spent on dementia research, rather than the £590m spent on cancer. It is important to see dementia as a disease and one that we need to better understand so that we can tackle it."
Experts and health officials from other G8 countries are expected to attend.
Mr Cameron told BBC Radio 4's You And Yours that more needs to be done to improve the lives of those with dementia.
Dr Gillings warned: "Just as the world came together in the fight against HIV/AIDS, we need to free up regulation so that we can test ground-breaking new drugs.
"So much of this is about making sure hospitals and care homes treat people with dementia better and, absolutely crucially, that we build dementia-friendly communities where all of us try and understand better what it's like to live with dementia," he said.
"The amount of scrutiny by regulators is considerable, but there probably needs to be a special case made for dementia by regulators so they can help move things through more quickly...
"Simplify the clinical trials process or simplify the sort of data being demanded."
Cancer v dementia research
Cancer v dementia research
UK government funded £52m of research into dementia in 2012/13
It has pledged to increase this to £66m by 2015
Around £600m is spent on cancer research each year
For every one dementia scientist in the UK, at least six work in cancer
Source: Alzheimer's Research UK
Source: Alzheimer's Research UK
Dr Gillings added that a major barrier to research was the "ratio of risk to reward" facing pharmaceutical companies investing in dementia.
Earlier, Alzheimer's Research UK announced a £100m research campaign and the Medical Research Council (MRC) said it was undertaking the world's biggest study into dementia, involving two million people.
Only three out of 104 dementia drugs assessed in clinical trials since 1998 have received regulatory approval.
The new world dementia envoy, Dennis Gillings, who was appointed by David Cameron in February, warned that if global leaders do not incentivise businesses to invest in research, the ambition to find a cure by 2025 will not be met.
Globally, research and development losses in dementia since then have reached around $50bn (£29bn).
Dr Gillings said: "Dementia is a ticking bomb costing the global economy £350bn and yet progress with research is achingly slow. Research must become more attractive to pharmaceuticals so they will invest and innovate.
A key reason for the lack of movement in this area, along with limited funding, is simply that research is extremely difficult.
"Just as the world came together in the fight against HIV/Aids, we need to free up regulation so that we can test groundbreaking new drugs, and examine whether the period for market exclusivity could be extended.
'Massive challenge'
"Without this radical change, we won't make progress in the fight against dementia."
"The brain is our most inaccessible organ," said Tim Parry from Alzheimer's Research UK.
Labour care spokeswoman Liz Kendall said her party supported the government's commitments to research funding, but wanted Mr Cameron to do more to help people currently struggling with dementia.
"We're looking to find the fault in the world's biggest supercomputer (our brains) but we're doing it in the dark. It's an absolutely massive challenge."
"Hundreds of thousands of people with dementia and their families are struggling without the vital local care services they desperately need. This isn't good for them, and is a false economy as an increasing number of elderly people with dementia are ending up in hospitals or care homes when they don't need to."
The charity is announcing a £100m research campaign as part of the summit, which will include the opening of a £2m Stem Cell Research Centre in Cambridge.
Dr Alison Cook, from the Alzheimer's Society, said the UK's best scientists should be given "the right environment to develop better treatments and ultimately a cure".
The centre - a collaboration between researchers at the Gurdon Institute at the University of Cambridge and University College London - aims to further understanding of the causes of Alzheimer's and screen potential new treatments.
She called for the industry to "step up" in order to deliver the G8 summit's pledge of a cure for dementia by 2025.
Its chief executive, Rebecca Wood, said investment would "feed innovative academic discoveries into the drug development pipeline, helping treatments to reach people with dementia more quickly".
"It's imperative that efforts to remove regulatory barriers are successful to allow new dementia research partnerships to thrive and deliver on their promise," she said.
The government will also announce the Medical Research Council's new UK Dementias Research Platform (UKDP) which it hopes will "speed up" research into dementia.
The £16m public-private partnership aims to enable earlier detection of dementia, improved treatment and - ultimately - prevention of the disease.
The key project will be the world's biggest study into dementia, involving two million people in the UK who scientists have already been tracking as part of other studies.
It will look at possible links between dementia and our lifestyles and other illnesses, rather than only focussing on changes in the brain.
'Heartbreaking'
Health Secretary Jeremy Hunt told BBC Breakfast the government was putting "the spotlight on dementia".
"We're asking the big question - if you're going to find a cure for this horrible disease... then what do you do to galvanise the drugs companies, to galvanise the other countries?" he said.
Mr Hunt added: "We've got this ambitious target of 2025 and we really want to go for it."
Jeremy Hughes, chief executive of the Alzheimer's Society, said: "Today's announcements mean the UK is leading the fight in dementia research but our global partners will be crucial to fulfilling the promise of the G8."
Dr John Gallacher of Cardiff University, director of the UKDP, said neurodegeneration could be linked with changes in parts of the body "seemingly unrelated" to the brain.
He said it was "imperative" to look at the different stages of developing the disease.
"By looking at the links between development of the disease and other factors - such as diet or illness - we hope to unearth targets for new drugs or new uses for existing drugs," he added.
Carol Franklin-Adams, whose husband Patrick has Alzheimer's disease, said: "We're all familiar with large campaigns of other charities but it's good to see dementia research starting to gain the recognition it deserves.
"It's heartbreaking to have a loved one with dementia, watching them slip away in front of your eyes.
"That very little can be done for someone with dementia today is the most tragic part of all, and while we can help with loving care, we remain powerless against the disease itself."
