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| Similar memories benefit from 'extra space' in brain | Similar memories benefit from 'extra space' in brain |
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| Similar memories overlap physically in the brain and this produces less confusion if the brain area responsible is larger, according to new research. | Similar memories overlap physically in the brain and this produces less confusion if the brain area responsible is larger, according to new research. |
| Scientists scanned the brains of 15 people recalling four similar scenes, in a study published in PNAS. | Scientists scanned the brains of 15 people recalling four similar scenes, in a study published in PNAS. |
| They spotted overlapping memory traces in a specific corner of the hippocampus called "CA3", a known memory area. | They spotted overlapping memory traces in a specific corner of the hippocampus called "CA3", a known memory area. |
| If their CA3 was bigger, the subjects were less confused and there was less overlap in the traces. | If their CA3 was bigger, the subjects were less confused and there was less overlap in the traces. |
| Most of us store many similar memories, relating to the places we spend most time and the people we know best. Normally we can tell them apart, though some of us may be better at it than others. | Most of us store many similar memories, relating to the places we spend most time and the people we know best. Normally we can tell them apart, though some of us may be better at it than others. |
| The CA3 region was thought to process each memory using distinct sets of brain cells. These findings suggest, however, that when two episodes incorporate similar content, they may in fact be "remembered" by physically overlapping networks - and more space could be beneficial. | The CA3 region was thought to process each memory using distinct sets of brain cells. These findings suggest, however, that when two episodes incorporate similar content, they may in fact be "remembered" by physically overlapping networks - and more space could be beneficial. |
| Greater capacity | Greater capacity |
| "Our results may help to explain why we sometimes find it difficult to differentiate between similar past memories, and why some people are better at doing this than others," said Prof Eleanor Maguire, the study's senior author, from the Wellcome Trust Centre for Neuroimaging at University College London (UCL). | "Our results may help to explain why we sometimes find it difficult to differentiate between similar past memories, and why some people are better at doing this than others," said Prof Eleanor Maguire, the study's senior author, from the Wellcome Trust Centre for Neuroimaging at University College London (UCL). |
| The 15 subjects watched four short movies, showing two different actions happening in each of two different places. They were then prompted to remember each one, 20 times over, inside a brain scanner. | The 15 subjects watched four short movies, showing two different actions happening in each of two different places. They were then prompted to remember each one, 20 times over, inside a brain scanner. |
| Scans revealed distinguishable memory activity in the CA3 region, but not three other compartments of the hippocampus. Importantly, the four different memory traces showed significant overlap. | Scans revealed distinguishable memory activity in the CA3 region, but not three other compartments of the hippocampus. Importantly, the four different memory traces showed significant overlap. |
| Furthermore, that overlap was more apparent in people who said they were more confused by the similarities between the four memories. | Furthermore, that overlap was more apparent in people who said they were more confused by the similarities between the four memories. |
| The scans combined fMRI (functional magnetic resonance imaging) with detailed structural measurements of each brain, so as well as getting a read-out of brain activity, the team could measure the exact size of each person's CA3. | The scans combined fMRI (functional magnetic resonance imaging) with detailed structural measurements of each brain, so as well as getting a read-out of brain activity, the team could measure the exact size of each person's CA3. |
| That was how they discovered that the size of this region, relative to the rest of the hippocampus, affected both the amount of overlap in the traces and the level of people's confusion. | That was how they discovered that the size of this region, relative to the rest of the hippocampus, affected both the amount of overlap in the traces and the level of people's confusion. |
| "A larger CA3 may contain more neurons or more connections between neurons, which could allow greater physical separation of the different memory traces," Dr Martin Chadwick, who conducted the experiments, told BBC News. | "A larger CA3 may contain more neurons or more connections between neurons, which could allow greater physical separation of the different memory traces," Dr Martin Chadwick, who conducted the experiments, told BBC News. |
| Although overall brain size is not related to different individuals' mental abilities (Einstein's brain was smaller than average), the relative dimensions of different components have been linked to various characteristics. | Although overall brain size is not related to different individuals' mental abilities (Einstein's brain was smaller than average), the relative dimensions of different components have been linked to various characteristics. |
| An earlier study by Prof Maguire famously showed that as they hone their impressive mental street maps and navigational ability, London cab drivers develop a larger hippocampus, on average, than the rest of us. | An earlier study by Prof Maguire famously showed that as they hone their impressive mental street maps and navigational ability, London cab drivers develop a larger hippocampus, on average, than the rest of us. |
| Dr Hugo Spiers, a neuroscience lecturer at UCL who was not involved in the research, described the new paper as a "really useful" addition to that classic finding. "[The hippocampus] is quite a lot of brain," he told the BBC. "What they've now found is that this particular bit within it, the CA3, which is a very exciting bit of the brain, is larger in some people." |